Childhood Cancer Epidemiology Group

Childhood Cancer Research Unit, Stockholm

Research

The CCEG carries out own research and supports other researchers. Through its registries the CCEG supports extensive network of clinical and translational scientists. This work has resulted in a large number of publications with data from the registries and statistical analysis done by the CCEG as important components.

Reports

Childhood Cancer Incidence and Survival in Sweden 1984-2010
Report 2013

This report contains information on all children
with cancer diagnosed in Sweden between 1984 and 2010.
Download Report

Publications

2011-   |   2001-2010   |   1991-2000   |   1970-1990

Jacobsen BB, Garwicz S, Glomstein A, Jonmundsson G, Kruus S, Yssing M. Medulloblastoma in Nordic children. III. Long term growth and endocrine sequelae. Acta Pædiatr Scand 1990;271:20-27.

Lie S, Berglund G, Gustafsson G, Jonmundsson G, Siimes M, Yssing M for NOPHO. High dose ARA-C as a single agent consolidation therapy in childhood AML. In: Haematology and Blood Transfusion. Acute Leukemia II. pp 215-221. Springer Verlag, 1990. PDF

Yssing M, Garwicz S, Glomstein A, Jonmundsson G, Kruus S. Medulloblastoma in Nordic children. II. Neurologic and social prognosis in long term survivors. Acta Pædiatr Scand 1990, suppl.371:12-19.

Gustafsson G, Berglund G, Garwicz S, Hertz H, Jonmundsson G, Moe PJ, Salmi TT, Seip M, Siimes MA, Yssing M for NOPHO. A population-based study of children with stanard risk acute lymphoblastic leukemia in the five Nordic countries. Acta Paediatr Scand 1989; 78: 104-109 PDF

Gustafsson G, Kreuger A. Behandlingsresultat för barn med akut lymfatisk leukemi 1973-1985 - en översikt. Läkartidningen 84: 623- 626, 1987. PDF

Gustafsson G, Garwicz S, Hertz H, Jonmundsson G, Johanesson G, Moe PJ, Salmi T, Seip M, Siimes MA, Yssing M and Åhström L for NOPHO. A Population-based study of childhood acute lymphoblastic leukemia diagnosed from July 1981 through June 1985 in the five Nordic countries. Acta Paediatr Scand 1987; 76: 781-788. PDF

Gustafsson G, Kreuger A. Akut lymfatisk leukemi hos barn- en översikt. Medicinsk kommentar. Läkartidningen 80: 2719-2720, 1983.

Gustafsson G, Kreuger A for SCLG. Sex as a prognostic factor in acute lymphoblastic leukemia in childhood. Am J Hematol Oncol 3: 243-250, 1983. PDF

Gustafsson G, Kreuger A for SCLG. Incidence of childhood leukemia in Sweden 1975-1980. Acta Paedriatr Scand 71: 887-892, 1982. PDF

Gustafsson G, Kreuger A, Dohlwitz A for SCLG. Acute lymfoblastic leukemia in Swedish children 1973-1978. Acta Paedriatr Scand 70: 609-614, 1981. PDF

Dohlwitz A, Gustafsson G, Kreuger A. Resultat av behandlingsprogram III för akut lymfatisk leukemi (1973-1976). Läkartidningen 76: 3069-72, 1979. PDF

Forestier E, Johansson B, Borgstrom G, Kerndrup G, Johansson J, Heim S. Cytogenetic findings in a population-based series of 787 childhood acute lymphoblastic leukemias from the Nordic countries. The NOPHO Leukemia Cytogenetic Study Group. Eur J Haematol. 2000 Mars; 64(3):194-200. PDF

Forestier E, Johansson B, Gustafsson G, Borgstrom G, Kerndrup G, Johannsson J, Heim S. Prognostic impact of karyotypic findings in childhood acute lymphoblastic leukaemia: a Nordic series comparing two treatment periods. For Nordic Society of Paediatric Haematology and Oncology and Leukaemia Cytogenetic Study Group. Br J Haematol. 2000 Jul;110(1):147-53. PDF

Gustafsson G, Schmiegelow K, Forestier E, Clausen N, Glomstein A, Jonmundsson G, Mellander L, Mäkipernaa A, Nygaard R, Saarinen-Pihkala U-M. Improving outcome through two decades in childhood ALL in the Nordic countries: the impacr of high-dose methotrexate in the reduction of CNS irradiation. Leukemia, 2000, 14: 2267-2275. PDF

Frost B-M, Gustafsson G, Larsson R, Nygren P, Lönnerholm G. Cellular cytotoxic drug sensitivity in children with acute leukemia and Down´s syndrome: an explanation to differences in clinical outcome? Leukemia, 2000, 14: 943-944. PDF

Schroeder H, Gustafsson G, Saarinen-Pihkala U, Glomstein A, Jonmundsson G, Nysom K, Ringden O and Mellander L. Allogeneic bone marrow transplantation in second remission of childhood acute lymphoblastic leukemia: a population-based case control study from the Nordic countries. Bone Marrow Transplant, 1999,Mar;23(6):555-560 PDF

Gustafsson G, Lie SO. Acute leukemias. In: Cancer in children, clinical management, 4th edn. (ed PA Voute, C Kalifa, A Barrett). Oxford University Press, London, 1998, 99-118.

Gustafsson G, Kreuger A, Clausen N, Garwicz S, Kristinsson J, Lie SO, Moe PJ, Perkkiö M, Yssing M and Saarinen-Pihkala U. Intensified treatment of acute childhood lymphoblastic leukemia has improved prognosis, especially in non-high-risk patients: the Nordic experience of 2648 patients diagnosed between 1981 and 1996. Acta Paediatr, 1998;87:1151-61. PDF

Jahnukainen K, Salmi TT, Kristinsson J, Müller J, Madsen B, Gustafsson G. The clinical indications for identical pathogenesis of isolated and non-isolated testicular relapse in acute lymphoblastic leukemia. Acta Paediatr,1998,87:638-643 PDF

Schmiegelow K, Glomstein A, Kristinsson J, Salmi T, Schroder H, Bjork O. Impact of morning versus evening schedule for oral methotrexate and 6-mercaptopurine on relapse risk for children with acute lymphoblastic leukemia. Nordic Society for Pediatric Hematology and Oncology (NOPHO). J Ped Hematol Oncol, 1997;19(2):102-9. PDF

Lie SO, Jonmundsson GK, Mellander L, Siimes MA, Yssing M, Gustafsson G. Chemotherapy of acute myelocytic leukemia in children. Ann N Y Acad Sci.1997;824:84-90. Review. PDF

Saarinen U, Mellander L, Nyström K, Ringden O, Schroeder H, Glomstein A and Gustafsson G for NOPHO. Allogeneic bone marrow transplantation in first remission for children with very high risk acute lymphoblastic leukemia: A retrospective case-control study in the Nordic countries. Bone Marrow Transplantation; 17 (3):357-363 1996. PDF

Lie S, Jonmundsson G, Mellander L, Siimes MA, Yssing M and Gustafsson G on behalf of NOPHO. A population based study of 272 children with acute myeloid leukemia treated on two consecutive protocols with different intensity: Best outcome in girls, infants and in children with Down´s syndrom. Br Journal of Hematology 1996; 94:82-88 PDF

Schröder H, Garwicz S, Gustafsson G, Kristinsson J, Siiemes MA and Wesenberg F on behalf of NOPHO. Outcome after relapse in children with acute lymphoblastic leukemia: a population-based study of 315 patients from the Nordic Society of Pediatric Hematology and Oncology (NOPHO). Med Ped Onc 1995; 25:372-378. PDF

Schmiegelow K, Schröder H, Gustafsson G, Kristinsson J, Glomstein A, Salmi T, and Wranne L for NOPHO. Risk of relapse in childhood acute lymphoblastic leukemia is related to RBC methotrexate and mercaptopurine metabolites during maintenance chemotherapy. Nordic Society for Pediatric Hematology and Oncology. Journal Clin Oncol 1995; 13:345-351. PDF

Marky I, Jonsson O, Kreuger A, Gustafsson G, Perkkio M, Schmiegelow K, Storm-Mathiesen I and Langmark F. Childhood Non-Hodgkin´s Lymphoma (NHL) in the five Nordic countries. A five year population based study. Am Journal Pediatr Hem/Onc.; 17(2): 163-166, 1995. PDF

Siimes MA, Lie SO, Andersen O, Marky I, Rautonen J, Hertz H. Prophylactic cranial irradiation increases the risk of testicular damage in adult males surviving ALL in childhood. Med Ped Oncol 1993;21:117-121. PDF

Lanning M, Garwitz S, Hertz H, Jonmundsson G, Kreuger A, Lie SO, Moe PJ, Salmi TT, Schröder H, Siimes M, Wesenberg F, Yssing M, Åhström L and Gustafsson G for NOPHO. Superior treatment results in females with high-risk acute lymphoblastic leukemia in childhood. Acta Paediatr Scand 1992; 81:66-68. PDF

Lie Sverre and Gustafsson Göran on behalf of the Nordic Society for Pediatric Hematology and Oncology (NOPHO). Progress in the treatment of childhood leukemias. Review article Annals of Medicin 1992; 24:319-323. PDF

Kreuger A, Garwitz S, Hertz H, Jonmundsson G, Lanning M, Lie SO, Moe PJ, Salmi TT, Schroeder H, Siimes MA, Wesenberg F, Yssing M, Åhström L and Gustafsson G for NOPHO. Central nervous system disease in childhood acute lymphoblastic leukemia: Prognostic factors and results of treatment. Pediatr Hem Oncol 1991; 8:291-299. PDF

Nygaard R, Clausen N, Siimes MA, Marky I, Skjeldestad FE, Kristinsson JR, Vuoristo A, Wegelius R, Moe PJ. Reproduction following treatment for childhood leukemia: A population-based prospective cohort study of fertility and offspring. Med Ped Oncol 1991;19:459-466. PDF

Nygaard R, Garwicz S, Haldorsen T, Hertz H, Jonmundsson GK, Lanning M, Moe PJ. Second malignant neoplasms in patients treated for childhood leukemia. A population-based cohort study from the Nordic countries. Acta Pædiatr Scand 1991;80:1220-1228. PDF

Molgaard-Hansen L, Möttönen M, Glosli H, Jónmundsson GK, Abrahamsson J, Hasle H; Nordic Society of Paediatric Haematology and Oncology (NOPHO). Early and treatment-related deaths in childhood acute myeloid leukaemia in the Nordic countries: 1984-2003. Br J Haematol. 2010 Dec;151(5):447-59. PDF

Schmidt LS, Kamper-Jørgensen M, Schmiegelow K, Johansen C, Lähteenmäki P, Träger C, Stokland T, Grell K, Gustafson G, Kogner P, Sehested A, Schüz J. Infectious exposure in the first years of life and risk of central nervous system tumours in children: analysis of birth order, childcare attendance and seasonality of birth. Br J Cancer. 2010 May 25;102(11):1670-5. PDF

Schüz J, Schmidt LS, Kogner P, Lähteenmäki PM, Pal N, Stokland T, Schmiegelow K. Birth characteristics and Wilms tumours in children in the Nordic countries: A register-based case-control study. Int J Cancer. 128: 2166-73, 2010. PDF

Carén H, Kryh H, Nethander M, Sjöberg RM, Träger C, Nilsson S, Abrahamsson J, Kogner P, Martinsson T. High-risk neuroblastoma tumors with 11q deletion display a poor prognostic, chromosome instability phenotype with later onset. Proc Natl Acad Sci U S A. 107:4323-8, 2010. PDF

Schmiegelow K, Heyman M, Gustafsson G, Lausen B, Wesenberg F, Kristinsson J, Vettenranta K, Schroeder H, Forestier E, Rosthoej S; Nordic Society of Paediatric Haematology and Oncology (NOPHO). The degree of myelosuppression during maintenance therapy of adolescents with B-lineage intermediate risk acute lymphoblastic leukemia predicts risk of relapse. Leukemia. 2010 Apr;24(4):715-20. PDF

Schmidt LS, Schüz J, Lähteenmäki P, Träger C, Stokland T, Gustafson G, Hjalgrim L, Sehested A, Johansen C, Schmiegelow K. Fetal growth, preterm birth, neonatal stress and risk for CNS tumors in children: a Nordic population- and register-based case-control study. Cancer Epidemiol Biomarkers Prev. 2010 Apr;19(4):1042-52. PDF

chmiegelow K, Forestier E, Hellebostad M, Heyman M, Kristinsson J, Söderhäll S, Taskinen M; Nordic Society of Paediatric Haematology and Oncology. Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia. Leukemia. 2010 Feb;24(2):345-54. Erratum in: Leukemia. 2010 Mar;24(3):670. PDF

Lannering B, Sandström PE, Holm S, Lundgren J, Pfeifer S, Samuelsson U, Strömberg B, Gustafsson G; Swedish Childhood CNS Tumor Working Group (VCTB). Classification, incidence and survival analyses of children with CNS tumours diagnosed in Sweden 1984-2005. Acta Paediatr. 2009 Oct;98(10):1620-7. PDF

Karrman K, Forestier E, Heyman M, Andersen MK, Autio K, Blennow E, Borgström G, Ehrencrona H, Golovleva I, Heim S, Heinonen K, Hovland R, Johannsson JH, Kerndrup G, Nordgren A, Palmqvist L, Johansson B; Nordic Society of Pediatric Hematology, Oncology (NOPHO); Swedish Cytogenetic Leukemia Study Group (SCLSG); NOPHO Leukemia Cytogenetic Study Group (NLCSG). Clinical and cytogenetic features of a population-based consecutive series of 285 pediatric T-cell acute lymphoblastic leukemias: rare T-cell receptor gene rearrangements are associated with poor outcome. Genes Chromosomes Cancer. 2009 Sep;48(9):795-805. PDF

Boman KK, Hovén E, Anclair M, Lannering B, Gustafsson G. Health and persistent functional late effects in adult survivors of childhood CNS tumours: a population-based cohort study. Eur J Cancer. 2009 Sep;45(14):2552-61. PDF

Schmiegelow K, Heyman M, Kristinsson J, Mogensen UB, Rosthøj S, Vettenranta K, Wesenberg F, Saarinen-Pihkala U; Nordic Society of Paediatric Haematology and Oncology (NOPHO). Oral methotrexate/6-mercaptopurine may be superior to a multidrug LSA2L2 Maintenance therapy for higher risk childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study. J Pediatr Hematol Oncol. 2009 Jun;31(6):385-92. PDF

Schmiegelow K, Al-Modhwahi I, Andersen MK, Behrendtz M, Forestier E, Hasle H, Heyman M, Kristinsson J, Nersting J, Nygaard R, Svendsen AL, Vettenranta K, Weinshilboum R; Nordic Society for Paediatric Haematology and Oncology. Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study. Blood. 2009 Jun 11;113(24):6077-84. PDF

Schmiegelow K, Forestier E, Kristinsson J, Söderhäll S, Vettenranta K, Weinshilboum R, Wesenberg F; Nordic Society of Paediatric Haematology and Oncology. Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study. Leukemia. 2009 Mar;23(3):557-64. PDF

Lönnerholm G, Frost BM, Abrahamsson J, Behrendtz M, Castor A, Forestier E, Heyman M, Uges DR, de Graaf SS. Vincristine pharmacokinetics is related to clinical outcome in children with standard risk acute lymphoblastic leukemia. Br J Haematol. 2008 Aug;142(4):616-21. PDF

Forestier E, Heyman M, Andersen MK, Autio K, Blennow E, Borgström G, Golovleva I, Heim S, Heinonen K, Hovland R, Johannsson JH, Kerndrup G, Nordgren A, Rosenquist R, Swolin B, Johansson B; Nordic Society of Paediatric Haematology, Oncology (NOPHO); Swedish Cytogenetic Leukaemia Study Group (SCLSG); NOPHO Leukaemia Cytogenetic Study Group (NLCSG). Outcome of ETV6/RUNX1-positive childhood acute lymphoblastic leukaemia in the NOPHO-ALL-1992 protocol: frequent late relapses but good overall survival. Br J Haematol. 2008 Mar;140(6):665-72. PDF

Forestier E, Gauffin F, Andersen MK, Autio K, Borgström G, Golovleva I, Gustafsson B, Heim S, Heinonen K, Heyman M, Hovland R, Johannsson JH, Kerndrup G, Rosenquist R, Schoumans J, Swolin B, Johansson B, Nordgren A; Nordic Society of Pediatric Hematology and Oncology; Swedish Cytogenetic Leukemia Study Group; NOPHO Leukemia Cytogenetic Study Group. Clinical and cytogenetic features of pediatric dic(9;20)(p13.2;q11.2)-positive B-cell precursor acute lymphoblastic leukemias: a Nordic series of 24 cases and review of the literature. Genes Chromosomes Cancer. 2008 Feb;47(2):149-58. Review. PDF

Forestier E, Andersen MK, Autio K, Blennow E, Borgström G, Golovleva I, Heim S, Heinonen K, Hovland R, Johannsson JH, Kerndrup G, Nordgren A, Rosenquist R, Swolin B, Johansson B; Nordic Society of Pediatric Hematology and Oncology (NOPHO); Swedish Cytogenetic Leukemia Study Group (SCLSG); NOPHO Leukemia Cytogenetic Study Group (NLCSG). Cytogenetic patterns in ETV6/RUNX1-positive pediatric B-cell precursor acute lymphoblastic leukemia: A Nordic series of 245 cases and review of the literature. Genes Chromosomes Cancer. 2007 May;46(5):440-50. PDF

Abrahamsson J, Clausen N, Gustafsson G, Hovi L, Jonmundsson G, Zeller B, Forestier E, Heldrup J, Hasle H. Improved outcome after relapse in children with acute myeloid leukaemia. British J of Haematol 2007; 136: 229-236. PDF

Hallböök H, Gustafsson G, Smedmyr B, Söderhäll S, Heyman M for the Swedish Adult ALL Group and the Swedish Childhood Leukemia Group. Treatment outcome in young adults and children over 10 years of age with ALL in Sweden: A comparison between pediatric protocol and an adult protocol. Cancer 2006; 107: 1551-156 . PDF

Palle J, Frost BM, Peterson C, Gustafsson G, Hellebostad M, Kanerva J, Schmiegelow K, Lönnerholm G. Doxorubicin pharmacokinetics is correlated to the effect of induction therapy in children with acute myeloid leukemia. Anticancer Drugs 2006; 17:385-392. PDF

Palle J, Frost BM, Peterson C, Gustafsson G, Hellebostad M, Kanerva J, Schmiegelow K, Lönnerholm G. Etoposide pharmacokinetics in children treated for acute myeloid leukemia. Anti-Cancer Drugs 2006; 17:1087-1094. PDF

Saarinen-Pihkala UM, Heilmann C, Winiarski J, Glomstein A, Abrahamsson J, Arvidson J, Békàssy AN, Forestier E, Jonmundson G, Schroeder H, Vettenranta K, Gustafsson G: Pathways through relapses and deaths of children with acute lymphoblastic leukemia: Role of allogeneic stem-cell transplantation in Nordic data. J Clin Oncol 24:5750-5762, 2006. PDF

Abildgaard L, Ellebæk E, Gustafsson G, Abrahamsson J, Hovi L, Jonmundsson G, Zeller B, Hasle H. Optimal treatment intensity in children with Down syndrome and myeloid leukaemia: data from 56 children treated on NOPHO-AML protocols and a review of the literature. Annals of Hematology 85:275-280. 2006. PDF

Forestier E, Schmiegelow K. The incidence peaks of the childhood acute leukemias reflect specific cytogenetic aberrations. J Pediatric Hem Onc, 28:486-95, 2006. PDF

Frost BM, Forestier E, Gustafsson G, Nygren P, Hellebostad M, Jonmundsson G, Kanerva J, Schmiegelow K, Larsson R, Lonnerholm G; Nordic Society for Paediatric Haematology and Oncology. Translocation t(1;19) is related to low cellular drug resistance in childhood acute Lymphoblastic leukaemia. Leukemia. 2005 Jan;19(1):165-9. PDF

Zeller B, Gustafsson G, Forestier E, Abrahamsson J, Clausen N, Heldrup J, Hovi L, Jonmundsson G, Lie SO, Glomstein A, Hasle H; Nordic Society of Paediatric Haematology and Oncology (NOPHO). Acute leukaemia in children with Down syndrome: a population-based Nordic study. Br J Haematol. 2005 Mar;128(6):797-804. PDF

Palle J, Frost BM, Forestier E, Gustafsson G, Nygren P, Hellebostad M, Jonsson OG, Kanerva J, Schmiegelow K, Larsson R, Lonnerholm G; on behalf of the Nordic Society for Paediatric Haematology and Oncology. Cellular drug sensitivity in MLL-rearranged childhood acute leukaemia is correlated to partner genes and cell lineage. Br J Haematol. 2005 Apr;129(2):189-98. PDF

Schmiegelow K, Gustafsson G. Acute lymphoblastic leukemias. In: Cancer in children, clinical management, 5th edn. (ed. Voute PA, Barrett A, Stevens M, Caron H). Oxford University Press, London, 2005138-170.

Lie SO, Abrahamsson J, Clausen N, Forestier E, Hasle H, Hovi L, Jonmundsson G, Mellander L, Siimes MA, Yssing M, Zeller B, Gustafsson G. Long-term results in children with AML: NOPHO-AML study group – report of three consecutive trials. Leukemia 2005; 19:2090-2100. PDF

Saarinen-Pihkala UM, Gustafsson G, Carlsen N, Flaegstad T, Glomstein A, Kristinsson J, Lanning M, Schroeder H, Mellander L on behalf of NOPHO. Outcome of children with high-risk acute lymphoblastic leukemia (HR-ALL): Nordic results on an intensive regimen with restricted central nervous system irradiation. Ped Blood Cancer 2004; 1: 16-26. PDF

Frost BM, Forestier E, Gustafsson G, Nygren P, Hellebostad M, Jonsson OG, Kanerva J, Schmiegelow K, Larsson R, Lonnerholm G. Translocation t(12;21) is related to in vitro cellular drug sensitivity to doxorubicin and etoposide in childhood acute lymphoblastic leukemia. Blood 2004 Oct 15;104(8):2452-7. PDF

Schmiegelow K, Bjork O, Glomstein A, Gustafsson G, Keiding N, Kristinsson J, Makipernaa A, Rosthoj S, Szumlanski C, Sorensen TM, Weinshilboum R. Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia. J Clin Oncol 2003 Apr 1;21(7):1332 PDF

Lie SO, Abrahamsson J, Clausen N, Forestier E, Hasle H, Hovi L, Jonmundsson G, Mellander L and Gustafsson G. Treatment stratification based on initial in vivo response in acute myeloid leukaemia in children without Down's syndrome: results of NOPHO-AML trials. Br J Haematol.2003 Jul; 122(2): 217- PDF

Frost BM, Nygren P, Gustafsson G, Forestier E, Jonsson OG, Kanerva J, Nygaard R, Schmiegelow K, Larsson R, Lönnerholm G. On behalf of NOPHO. Increased in vitro cellular drug resistance is related to poor outcome in high-risk childhood acute lymphoblastic leukaemia. Br J Haematol. 2003 Aug; 122(3): 376-85. PDF

Hjalgrim LL, Rostgaard K, Schmiegelow K, Soderhall S, Kolmannskog S, Vettenranta K, Kristinsson J, Clausen N, Melbye M, Hjalgrim H, Gustafsson G. Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countries. J Natl Cancer Inst. 2003 Oct 15; 95(20): 1539-44. PDF

T M Calero Moreno, G Gustafsson, S Garwicz, D Grandér, G K Jonmundsson, B-M Frost, A Mäkipernaa, O Rasool, E-R Savolainen, K Schmiegelow, S Söderhäll, K Vettenranta, F Wesenberg,  S Einhorn, M Heyman. Deletion of the ink4-locus (the p16ink4a, p14ARF and ND p15ink4b genes) predicts relapse in children with ALL treated according to the Nordic Protocols NOPHO-86 and NOPHO-92. Leukemia, 2002, 16, 2037-2045. PDF

Frost B-M, Eksborg S, Björk O, Abrahamsson J, Behrendz M, Castor A, Forestier E, Lönnerholm G. Pharmacokinetics of doxorubicin in children with acute lymphoblastic leukemia: multi-institutional collaborative study. Med Pediatr Oncol, 2002; 38:329-337. PDF

Lie SO, Clausen N, Jonmundsson G, Mellander L, Siimes MA, Gustafsson G, on behalf of the Nordic Society for Pediatric Hematology and Oncology (NOPHO). Early response to therapy is the strongest prognostic factor in childhood AML. Acute Leukemias VIII. Prognostic and Treatment Strategies, Springer 2001; 499-507

Saarinen-Pihkala UM, Gustafsson G, Ringdén O. et al. No disadvantage in outcome of using matched unrelated donors as compared with matched sibling donors for bone marrow transplantation in children with acute lymphoblastic leukemia in second remission. J Clin Oncol; 19:3406-3414, 2001. PDF

Molgaard-Hansen L, Skou AS, Juul A, Glosli H, Jahnukainen K, Jarfelt M, Jónmundsson GK, Malmros J, Nysom K, Hasle H; On behalf of the Nordic Society of Pediatric Hematology and Oncology (NOPHO). Pubertal development and fertility in survivors of childhood acute myeloid leukemia treated with chemotherapy only: A NOPHO-AML study. Pediatr Blood Cancer. 2013 Aug 23. doi: 10.1002/pbc.24715. [Epub ahead of print] PDF

Olsson L, Castor A, Behrendtz M, Biloglav A, Forestier E, Paulsson K, Johansson B. Deletions of IKZF1 and SPRED1 are associated with poor prognosis in a population-based series of pediatric B-cell precursor acute lymphoblastic leukemia diagnosed between 1992 and 2011. Leukemia. 2013 Jul 4. doi: 10.1038/leu.2013.206. [Epub ahead of print] PDF

Schmiegelow K, Levinsen MF, Attarbaschi A, Baruchel A, Devidas M, Escherich G, Gibson B, Heydrich C, Horibe K, Ishida Y, Liang DC, Locatelli F, Michel G, Pieters R, Piette C, Pui CH, Raimondi S, Silverman L, Stanulla M, Stark B, Winick N, Valsecchi MG. Second malignant neoplasms after treatment of childhood acute lymphoblastic leukemia. J Clin Oncol. 31, 2469-2476, 2013. Epub 2013 May 20. PDF

Paulsson K, Forestier E, Andersen MK, Autio K, Barbany G, Borgström G, Cavelier L, Golovleva I, Heim S, Heinonen K, Hovland R, Johannsson JH, Kjeldsen E, Nordgren A, Palmqvist L, Johansson B; Nordic Society of Pediatric Hematology and Oncology (NOPHO), the Swedish Cytogenetic Leukemia Study Group (SCLSG), and the NOPHO Leukemia Cytogenetic Study Group (NLCSG). High modal number and triple trisomies are highly correlated favorable factors in childhood B-cell precursor high hyperdiploid acute lymphoblastic leukemia treated according to the NOPHO ALL 1992/2000 protocols. Haematologica. 98, 1424-1432, 2013. Epub 2013 May 3. PDF

Vaitkeviciene G, Heyman M, Jonsson OG, Lausen B, Harila-Saari A, Stenmarker M, Taskinen M, Zvirblis T, Asberg A, Groth-Pedersen L, Rageliene L, Schmiegelow K. Early morbidity and mortality in childhood acute lymphoblastic leukemia with very high white blood cell count. Leukemia. 2013 May 2. doi: 10.1038/leu.2013.137. [Epub ahead of print] PDF

Toft N, Birgens H, Abrahamsson J, Bernell P, Griškevičius L, Hallböök H, Heyman M, Holm MS, Hulegårdh E, Klausen TW, Marquart HV, Jónsson OG, Nielsen OJ, Quist-Paulsen P, Taskinen M, Vaitkeviciene G, Vettenranta K, Åsberg A, Schmiegelow K. Risk group assignment differs for children and adults 1-45 yr with acute lymphoblastic leukemia treated by the NOPHO ALL-2008 protocol. Eur J Haematol. 90, 404-412, 2013. Epub 2013 Apr 2. PDF

Ofverholm I, Tran AN, Heyman M, Zachariadis V, Nordenskjöld M, Nordgren A, Barbany G. Impact of IKZF1 deletions and PAX5 amplifications in pediatric B-cell precursor ALL treated according to NOPHO protocols. Leukemia.27, 1936-1939, 2013. Epub 2013 Mar 29. PDF

Hovén EI, Lannering B, Gustafsson G, Boman KK. Persistent impact of illness on families of adult survivors of childhood central nervous system tumors: a population-based cohort study. Psychooncology. 2013 Jan;22(1):160-7. PDF

Boman K, Hörnquist L, de Graff Lisanne, Rickardsson J, Lannering B, Gustafsson G. Disability, body image and sports/physical activity in adult survivors of childhood CNS tumors: population-based outcomes from a cohort study. J Neurooncology 2013 Jan. PDF

Schrappe M, Hunger SP, Pui CH, Saha V, Gaynon PS, Baruchel A, Conter V, Otten J, Ohara A, Versluys AB, Escherich G, Heyman M, Silverman LB, Horibe K, Mann G, Camitta BM, Harbott J, Riehm H, Richards S, Devidas M, Zimmermann M. Outcomes after Induction Failure in Childhood Acute Lymphoblastic Leukemia. New Engl. J. of Med 366, 1371-1381, 2012. PDF

Mellgren K, Hedegaard CJ, Schmiegelow K, Müller K. Plasma cytokine profiles at diagnosis in pediatric patients with non-hodgkin lymphoma. J Pediatr Hematol Oncol. 34,271-275, 2012. PDF

Cetinkaya C, Martinsson T, Sandgren J, Träger C, Kogner P, Dumanski J, Díaz de Ståhl T, Hedborg F. Age dependence of tumor genetics in unfavorable neuroblastoma: arrayCGH profiles of 34 consecutive cases, using a Swedish 25-year neuroblastoma cohort for validation. BMC Cancer. 13, 231-245, 2013. PDF

Wareham NE, Heilmann C, Abrahamsson J, Forestier E, Gustafsson B, Ha SY, Heldrup J, Jahnukainen K, Jónsson OG, Lausen B, Palle J, Zeller B, Hasle H. Outcome of poor response paediatric AML using early SCT. Eur J Haematol. 2012 Dec 7. PDF

Bohnstedt C, Levinsen M, Rosthøj S, Zeller B, Taskinen M, Hafsteinsdottir S, Björgvinsdóttir H, Heyman M, Schmiegelow K. Physicians compliance during maintenance therapy in children with Down syndrome and acute lymphoblastic leukemia. Leukemia. 2012 Nov 9. PDF

Zachariadis V, Schoumans J, Barbany G, Heyman M, Forestier E, Johansson B, Nordenskjöld M, Nordgren A. Homozygous deletions of CDKN2A are present in all dic(9;20)(p13·2;q11·2)-positive B-cell precursor acute lymphoblastic leukaemias and may be important for leukaemic transformation. Br J Haematol. 159, 488-491, 2012. Epub 2012 Sep 21. PDF

Hasle H, Abrahamsson J, Forestier E, Ha SY, Heldrup J, Jahnukainen K, Jónsson ÓG, Lausen B, Palle J, Zeller B; Nordic Society of Paediatric Haematology and Oncology (NOPHO). Gemtuzumab ozogamicin as postconsolidation therapy does not prevent relapse in children with AML: results from NOPHO-AML 2004. Blood. 2012 Aug 2;120(5):978-84. PDF

Barbany G, Andersen MK, Autio K, Borgström G, Franco LC, Golovleva I, Heim S, Heinonen K, Hovland R, Johansson B, Johannsson JH, Kjeldsen E, Nordgren A, Palmqvist L, Forestier E; Nordic Society of Paediatric Haematology and Oncology; Swedish Cytogenetic Leukaemia Study Group; NOPHO Leukaemia Cytogenetic Study Group. Additional aberrations of the ETV6 and RUNX1 genes have no prognostic impact in 229 t(12;21)(p13;q22)-positive B-cell precursor acute lymphoblastic leukaemias treated according to the NOPHO-ALL-2000 protocol. Leuk Res. 2012 Jul;36(7):936-8. PDF

Levinsen M, Shabaneh D, Bohnstedt C, Harila-Saari A, Jonsson OG, Kanerva J, Lindblom A, Lund B, Andersen EW, Schmiegelow K; Nordic Society of Paediatric Haematology and Oncology (NOPHO). Pneumocystis jiroveci pneumonia prophylaxis during maintenance therapy influences methotrexate/6-mercaptopurine dosing but not event-free survival for childhood acute lymphoblastic leukemia. Eur J Haematol. 2012 Jan;88(1):78-86. PDF

Molgaard-Hansen L, Glosli H, Jahnukainen K, Jarfelt M, Jónmundsson GK, Malmros-Svennilson J, Nysom K, Hasle H; Nordic Society of Pediatric Hematology and Oncology. Quality of health in survivors of childhood acute myeloid leukemia treated with chemotherapy only: a NOPHO-AML study. Pediatr Blood Cancer. 2011 Dec 15;57(7):1222-9. PDF

Staffas A, Kanduri M, Hovland R, Rosenquist R, Ommen HB, Abrahamsson J, Forestier E, Jahnukainen K, Jónsson ÓG, Zeller B, Palle J, Lönnerholm G, Hasle H, Palmqvist L, Ehrencrona H; Nordic Society of Pediatric Hematology and Oncology (NOPHO). Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia. Blood. 2011 Nov 24;118(22):5905-13. PDF

Frandsen TL, Abrahamsson J, Lausen B, Vettenranta K, Heyman M, Behrentz M, Castor A, Wehner PS, Frost BM, Andersen EW, Schmiegelow K. Individualized toxicity-titrated 6-mercaptopurine increments during high-dose methotrexate consolidation treatment of lower risk childhood acute lymphoblastic leukaemia. A Nordic Society of Paediatric Haematology and Oncology (NOPHO) pilot study. Br J Haematol. 2011 Oct;155(2):244-7. PDF

Andersen MK, Autio K, Barbany G, Borgström G, Cavelier L, Golovleva I, Heim S, Heinonen K, Hovland R, Johannsson JH, Johansson B, Kjeldsen E, Nordgren A, Palmqvist L, Forestier E. Paediatric B-cell precursor acute lymphoblastic leukaemia with t(1;19)(q23;p13): clinical and cytogenetic characteristics of 47 cases from the Nordic countries treated according to NOPHO protocols. Br J Haematol. 2011 Oct;155(2):235-43. PDF

Hovén E, Lannering B, Gustafsson G, Boman KK. The met and unmet health care needs of adult survivors of childhood central nervous system tumors: a double-informant, population-based study. Cancer. 2011 Sep 15;117(18):4294-303. PDF

Schmiegelow K. Epidemiology of therapy-related myeloid neoplasms after treatment for pediatric acute lymphoblastic leukemia in the nordic countries. Mediterr J Hematol Infect Dis. 2011;3(1):e2011020. PDF

Ljungman G, Jakobson A, Behrendtz M, Ek T, Friberg LG, Hjalmars U, Hjorth L, Lindh J, Pal N, Sandstedt B, Österlundh G, Gustafsson G; Swedish Childhood Solid Tumour Working Group (VSTB). Incidence and survival analyses in children with solid tumours diagnosed in Sweden between 1983 and 2007. Acta Paediatr. 2011 May;100(5):750-7. PDF

Lund B, Åsberg A, Heyman M, Kanerva J, Harila-Saari A, Hasle H, Söderhäll S, Jónsson ÓG, Lydersen S, Schmiegelow K; Nordic Society of Paediatric Haematology and Oncology. Risk factors for treatment related mortality in childhood acute lymphoblastic leukaemia. Pediatr Blood Cancer. 2011 Apr;56(4):551-9. PDF

Zachariadis V, Gauffin F, Kuchinskaya E, Heyman M, Schoumans J, Blennow E, Gustafsson B, Barbany G, Golovleva I, Ehrencrona H, Cavelier L, Palmqvist L, Lönnerholm G, Nordenskjöld M, Johansson B, Forestier E, Nordgren A; Nordic Society of Pediatric Hematology, Oncology (NOPHO); Swedish Cytogenetic Leukemia Study Group (SCLSG). The frequency and prognostic impact of dic(9;20)(p13.2;q11.2) in childhood B-cell precursor acute lymphoblastic leukemia: results from the NOPHO ALL-2000 trial. Leukemia. 2011 Apr;25(4):622-8. PDF

Molgaard-Hansen L, Möttönen M, Glosli H, Jónmundsson GK, Abrahamsson J, Hasle H; Nordic Society of Paediatric Haematology and Oncology (NOPHO). Treatment-related deaths in second complete remission in childhood acute myeloid leukaemia. Br J Haematol. 2011 Mar;152(5):623-30. PDF

Kuchinskaya E, Heyman M, Nordgren A, Söderhäll S, Forestier E, Wehner P, Vettenranta K, Jonsson O, Wesenberg F, Sahlén S, Nordenskjöld M, Blennow E. Interphase fluorescent in situ hybridization deletion analysis of the 9p21 region and prognosis in childhood acute lymphoblastic leukaemia (ALL): results from a prospective analysis of 519 Nordic patients treated according to the NOPHO-ALL 2000 protocol. Br J Haematol. 2011 Mar;152(5):615-22. PDF

Schmidt LS, Schmiegelow K, Lahteenmaki P, Träger C, Stokland T, Grell K, Gustafson G, Sehested A, Raashou-Nielsen O, Johansen C, Schüz J. Incidence of childhood central nervous system tumors in the Nordic countries. Pediatr Blood Cancer. 2011 Jan;56(1):65-9. PDF

Abrahamsson J, Forestier E, Heldrup J, Jahnukainen K, Jónsson OG, Lausen B, Palle J, Zeller B, Hasle H. Response-guided induction therapy in pediatric acute myeloid leukemia with excellent remission rate. J Clin Oncol. 2011 Jan 20;29(3):310-5. PDF

Vaitkevičienė G, Forestier E, Hellebostad M, Heyman M, Jonsson OG, Lähteenmäki PM, Rosthoej S, Söderhäll S, Schmiegelow K; Nordic Society of Paediatric Haematology and Oncology (NOPHO). High white blood cell count at diagnosis of childhood acute lymphoblastic leukaemia: biological background and prognostic impact. Results from the NOPHO ALL-92 and ALL-2000 studies. Eur J Haematol. 2011 Jan;86(1):38-46. PDF